Our colleague Dr. Ludovic Gremaud and his team discover pentacyclic product derivative from the natural product perophoramidine, as a formidable anticancer agent
ChemTech

Natural products have directly influenced many drug-discovery endeavors.

Prof. Dr. Ludovic Gremaud, Prof. Dr. Subhabrata Sen and their teams have reported the discovery of a pentacyclic product (mean that is a compound with 5 rings, Fragment B), derivative from the natural product Perophoramidine, as a formidable anticancer agent. The Fragment B derivatives were synthesized in six steps where the key steps involved a green and sustainable photochemical methodology. Biological tests of the Fragment B derivatives against breast and lung cancer as well as colon tumor demonstrated very high activity and revealed extensive DNA damage to cancereous cells.

All these results are the fruit of a strong and intense collaboration between Shiv Nadar University New Dehli, India and the ChemTech institute. We look forward to future collaborations!

To read the full paper, click here.

8. November 2022